Research from the National Jewish Research and Medical Center, Denver-CO

Health Effects of Air Pollution
The human health effects of poor air quality are far reaching, but principally affect the body's respiratory system and the cardiovascular system. Individual reactions to air pollutants depend on the type of pollutant a person is exposed to, the degree of exposure, the individual's health status and genetics. People who exercise outdoors, for example, on hot, smoggy days increase their exposure to pollutants in the air.
The health effects caused by air pollutants may range from subtle biochemical and physiological changes to difficulty breathing, wheezing, coughing and aggravation of existing respiratory and cardiac conditions. These effects can result in increased medication use, increased doctor or emergency room visits, more hospital admissions and even premature death.

Human Respiratory System
The health of our lungs and entire respiratory system is affected by the quality of the air we breathe. In addition to oxygen, this air contains other substances such as pollutants, which can be harmful. Exposure to chemicals by inhalation can negatively affect our lungs and other organs in the body. The respiratory system is particularly sensitive to air pollutants because much of it is made up of exposed membrane. Lungs are anatomically structured to bring large quantities of air (on average, 400 million litres in a lifetime) into intimate contact with the blood system, to facilitate the delivery of oxygen.

Lung tissue cells can be injured directly by air pollutants such as ozone, metals and free radicals. Ozone can damage the alveoli -- the individual air sacs in the lung where oxygen and carbon dioxide are exchanged. More specifically, airway tissues which are rich in bioactivation enzymes can transform organic pollutants into reactive metabolites and cause secondary lung injury. Lung tissue has an abundant blood supply that can carry toxic substances and their metabolites to distant organs. In response to toxic insult, lung cells also release a variety of potent chemical mediators that may critically affect the function of other organs such as those of the cardiovascular system. This response may also cause lung inflammation and impair lung function.

Structure and Function
The human respiratory system is dominated by our lungs, which bring fresh oxygen (O2) into our bodies while expelling carbon dioxide (CO2). The oxygen travels from the lungs through the bloodstream to the cells in all parts of the body. The cells use the oxygen as fuel and give off carbon dioxide as a waste gas. The waste gas is carried by the bloodstream back to the lungs to be exhaled.
The lungs accomplish this vital process - called gas exchange - using an automatic and quickly adjusting control system. This gas exchange process occurs in conjunction with the central nervous system (CNS), the circulatory system, and the musculature of the diaphragm and the chest.
The human respiratory system can be divided into the upper respiratory tract and the lower respiratory tract. The upper respiratory tract includes the following rigid structures:
Nasal cavities: Filter the air we breathe and provide a sense of smell.
Pharynx: Acts in the respiratory and the digestive system.
Larynx: Link between the pharynx and the trachea. Generates the voice with the presence of vocal folds.
Trachea: The trachea is the bond with the lower respiratory tract. This is a flexible structure allowing the air to go down to the lungs.
In addition to gas exchange, the lungs and the other parts of the respiratory system have important jobs to do related to breathing. These include:
Bringing all air to the proper body temperature.
Moisturizing the inhaled air for necessary humidity.
Protecting the body from harmful substances by coughing, sneezing, filtering or swallowing them, or by alerting the body through the sense of smell.
Defending the lungs with cilia (tiny hair-like structure), mucus and macrophages, which act to remove harmful substances deposited in the respiratory system.

The respiratory system is sensitive to air pollution. The cardiovascular system can be affected as well.Many chemical substances may cause the formation of reactive oxygen. This oxidative metabolism is considered to be critical to the preservation of cardiovascular function. For example, oxygen free radicals oxidize low-density lipoproteins, and this reaction is thought to be involved in the formation of the atherosclerotic plaques. Oxidized low-density lipoproteins can injure blood vessel cells and increase adherence and the migration of inflammatory cells to the injured area. The production of oxygen free radicals in heart tissues have been associated with arrhythmias, and heart cell death.

The role of air pollution as the underlying cause remains unclear but is the subject of considerable research. However, it is clear that air pollution, infections and allergies can exacerbate these conditions. An early diagnosis can lead to appropriate treatment and ensure a normal or close to normal quality of life. In many cases however, there is no cure and those affected may die prematurely. The following are the most prevalent diseases:
Minor Lung Illnesses - the common cold is the most familiar of these, with symptoms including sore throat, stuffy or runny nose, coughing and sometimes irritation of the eyes.
Lung Infections - croup, bronchitis, and pneumonia are caused by viruses or bacteria and are very common. Symptoms may include cough, fever, chills and shortness of breath.
Asthma - is an increasingly common chronic disease among children and adults. It causes shortness of breath, coughing or wheezing or whistling in the chest. Asthma attacks can be triggered by a variety of factors including exercise, infection, pollen, allergies and stress. It can also be triggered by a sensitivity to non-allergic types of pollutants present in the air such as smog.
Chronic Obstructive Pulmonary Disease (COPD) - is also known as chronic obstructive lung disease and encompasses two major disorders: emphysema and chronic bronchitis. Emphysema is a chronic disorder in which the walls and elasticity of the alveoli are damaged. Chronic bronchitis is characterized by inflammation of the cells lining the inside of bronchi, which increases the risk of infection and obstructs airflow in and out of the lung. Smoking is responsible for approximately 80% of COPD cases while other forms of air pollution may also influence the development of these diseases. Symptoms include cough, production of mucous and shortness of breath. It is important to note that no cure exists for people suffering from COPD although healthy lifestyle and appropriate medication can help.

Air pollution can affect both the respiratory and cardiac systems. The health effects of air pollution can be seen as a pyramid, with the mildest but not common effects at the bottom of the pyramid, and the least common but more severe at the top of the pyramid. The pyramid demonstrates that as severity decreases the number of people affected increases.
Health Endpoints Associated with Increased Air Pollutants Levels
Mortality: All non-accidental mortality causes
Hospital Admissions: Cardiovascular and Respiratory Hospital Admissions
Emergency Room Visits: Visit to an emergency department
Asthma Symptom Days: Exacerbation of asthma symptoms in individuals with diagnosed asthma
Restricted Activity Days: Days spent in bed, missed from work, and days when activities are partially restricted due to illness
Acute Respiratory Symptoms: Respiratory-related symptoms such as chest discomfort, coughing and wheezing